RT Journal Article
T1 Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines
A1 Garcia Dominguez, Patricia
A1 Areal Gonzalez, Andrea
A1 Álvarez Rodríguez, Maria Rosana
A1 Rodríguez de Lera, Ángel
K1 2306 Química Orgánica
AB Within the 2,5-dioxopiperazines-containing natural products, those generated from tryptophan allow further structural diversification due to the rich chemical reactivity of the indole heterocycle. The great variety of natural products, ranging from simple dimeric bispyrrolidinoindoline dioxopiperazines and tryptophan-derived dioxopiperazine/pyrrolidinoindoline dioxopiperazine analogs to complex polycyclic downstream metabolites containing transannular connections between the subunits, will be covered. These natural products are constructed by Nature using hybrid polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) assembly lines. Mining of microbial genome sequences has more recently allowed the study of the metabolic routes and the discovery of their hidden biosynthetic potential. The competition (ideally, also the combined efforts) between their isolation from the cultures of the producing microorganisms after global genome mining and heterologous expression and the synthetic campaigns, has more recently allowed the successful generation and structural confirmation of these natural products. Their biological activities as well as their proposed biogenetic routes and computational studies on biogenesis will also be covered.
PB Natural Product Reports
SN 02650568
YR 2022
FD 2022
LK http://hdl.handle.net/11093/8043
UL http://hdl.handle.net/11093/8043
LA eng
NO Natural Product Reports, 39(6): 1172-1225 (2022)
NO Agencia Estatal de Investigación | Ref. PID2019-107855RB-I00
DS Investigo
RD 26-mar-2025