RT Dissertation/Thesis
T1 Clinical impact of current initial antiretroviral drug combinations on virological non-suppression and inflammation biomarkers, in HIV infection.
T2 Impacto clínico de las actuales combinaciones de fármacos antirretrovirales de inicio sobre la viremia no suprimida y marcadores de inflamación, en la infección por el VIH.
A1 Álvarez Díaz, Hortensia
K1 2420 Virología
K1 3205.05 Enfermedades Infecciosas
AB Background. Antiretroviral therapy (ART) has allowed a dramatic reduction in Human Immunodeficiency Virus (HIV)-related morbidity and mortality. Current ART combinations effectively suppress HIV replication for a long-time and preserve the immune system of the patients. However, the long-term efficacy of ART could be jeopardized in subjects with low-level viremia (LLV) and residual viremia (RV) which could be related with incomplete HIV suppression. There are some incompletely understood issues regarding the LLV and RV definitions and measurements as well as the interpretation of the impact on subsequent virological failure and potential emergence of drug resistance mutations developed under the selective pressure of a drug in the absence of full viral suppression.Objectives.The aim of this project is to prospectively evaluate the impact of different drug combinations on rates of virological non-suppression and cytokines dynamics, among HIV-infected patients who start ART.Study population and procedure.Observational study. Data and samples of patients will be retrieved from a nationwide cohort and processed at the Biobank of Galicia Sur Health Research Institute, in Vigo.Expected results.The results obtained in this study could identify determinants and drugs associated with virological non-suppression, resulting in prevention of the development of drug resistance mutations during ART.
LK http://hdl.handle.net/11093/7693
UL http://hdl.handle.net/11093/7693
LA eng
DS Investigo
RD 24-mar-2025