RT Journal Article
T1 Toward smart implant synthesis: bonding bioceramics of different resorbability to match bone growth rates
A1 Comesaña Piñeiro, Rafael
A1 Lusquiños Rodríguez, Fernando
A1 Del Val Garcia, Jesús
A1 Quintero Martínez, Félix
A1 Riveiro Rodríguez, Antonio
A1 Boutinguiza Larosi, Mohamed
A1 Jones, Julian Raymond
A1 Hill, Robert G
A1 Pou Saracho, Juan María
K1 3307.07 Dispositivos láser
AB Craniofacial reconstructive surgery requires a bioactive bone implant capable to provide a gradual resorbability and to adjust to the kinetics of new bone formation during healing. Biomaterials made of calcium phosphate or bioactive glasses are currently available, mainly as bone defect fillers, but it is still required a versatile processing technique to fabricate composition-gradient bioceramics for application as controlled resorption implants. Here it is reported the application of rapid prototyping based on laser cladding to produce three-dimensional bioceramic implants comprising of a calcium phosphate inner core, with moderate in vitro degradation at physiological pH, surrounded by a bioactive glass outer layer of higher degradability. Each component of the implant is validated in terms of chemical and physical properties and absence of toxicity. Pre–osteoblastic cell adhesion and proliferation assays reveal the adherence and growth of new bone cells on the material. This technique affords implants with gradual-resorbability for restoration of low-load-bearing bone.
PB Scientific Reports
SN 20452322
YR 2015
FD 2015-06-02
LK http://hdl.handle.net/11093/6505
UL http://hdl.handle.net/11093/6505
LA eng
NO Scientific Reports, 5(1): * (2015)
NO Ministerio de Educación y Ciencia | Ref. MAT2006-10481
DS Investigo
RD 13-dic-2024