RT Dissertation/Thesis
T1 Enantioselective synthesis of allenophanes for molecular recognition
T2 Síntesis enantioselectiva de alenófanos para reconocimiento molecular
A1 Rubio Pisabarro, Victor
K1 2306 Química Orgánica
AB The research is directed towards unraveling the fundamental mechanisms responsible for the cooperative expression of molecular chirality in molecular recognition event, specifically, the formation of host-guest inclusion complexes and self-assembly processes, employing chiroptical spectroscopy and NMR.For this purpose, novel chiral cyclic structures capable of recognizing biologically or environmentally significant small molecules (species containing ammonium groups) and exhibiting chiroptical responses to complexation will be designed. Various macrocycles incorporating diethynylallenes (DEAs) and functionalized aromatic spacers will be synthesized and characterized, with a focus on differently functionalized pyrazines and pyridines as primary subjects of investigation. The diverse functionalization of the molecules under study will enable the attachment of considerably varied subunits, facilitating the examination of modifications in macrocycle properties based on each substitution.Our research group holds expertise in studying host-guest complexes using UV-Vis/CD, NMR, and X-ray diffraction. The exploration of molecular recognition of biologically relevant species by the synthesized structures primarily occurs through hydrogen bonds and hydrophobic interactions.In our investigation, we aim to elucidate pivotal aspects related to ion transport across membranes, such as in cystic fibrosis, and pH variations in cancer processes.
YR 2024
FD 2024-03-08T08:33:43Z
LK http://hdl.handle.net/11093/6411
UL http://hdl.handle.net/11093/6411
LA eng
DS Investigo
RD 14-dic-2024