RT Journal Article T1 Effect of olive ripening degree on the antidiabetic potential of biophenols-rich extracts of Brava Gallega virgin olive oils A1 Reboredo Rodríguez, Patricia A1 Olmo García, L A1 Figueiredo González, María A1 González Barreiro, Carmen A1 Carrasco Pancorbo, Alegría A1 Cancho Grande, Beatriz K1 3309.28 Aceites y Grasas Vegetales K1 3309.03 Antioxidantes en Los Alimentos AB The diet management is imperative to anticipate risk factors that favour the development of diseases; indeed, the intake of virgin olive oil could be an alternative natural source of α-glucosidase enzyme inhibitors, which delay the digestion rate of carbohydrates. Consequently, the impact of diabetes mellitus (DM) could be diminished. Extra Virgin Olive Oils (EVOO) were elaborated from Galician autochthonous variety ‘Brava Gallega’ with olives selected at three different degree of ripeness (ripening index, RI: 1.4, 3.0, 5.5) in order to assess the effect of maturation on overall chemical composition, sensory quality, and enzyme inhibition. The phenolic profile of the EVOOs determined by LC-ESI-IT-MS exhibited quantitative differences as ripening advanced; for example oleocanthal, tyrosol, luteolin and apigenin concentrations were higher in the overripe olive oil (RI 5.5). Anyway, the phenolic extracts (from every tested RI) were more active than acarbose. In particular, those obtained from the most mature olives displayed the most powerful inhibitory activity (IC50 value of 143 µg of dry extract/mL). In addition, the significant effect of these compounds (i.e. luteolin, apigenin, tyrosol and oleocanthal) on the inhibitory activity of the olive oil extracts was demonstrated. Our results suggest that, regardless of RI, the inhibitory activity of ‘Brava Gallega’ olive oils could represent a valuable strategy for reinforcing the health claim of olive oil for phenolic compounds. PB Food Research International SN 09639969 YR 2020 FD 2020-11 LK http://hdl.handle.net/11093/6178 UL http://hdl.handle.net/11093/6178 LA eng NO Food Research International, 137, 109427 (2020) NO Agencia Estatal de Investigación | Ref. RTI2018-098633-B-I00 DS Investigo RD 25-ene-2025