RT Journal Article
T1 Does expert opinion match the definition of lupus low disease activity state? Prospective analysis of 500 patients from a Spanish multicentre cohort
A1 Altabás González, Irene
A1 Rúa Figueroa, Iñigo
A1 Rubiño, Francisco
A1 Mouriño Rodríguez, Coral
A1 Hernández Rodríguez, Iñigo
A1 Menor Almagro, Raul
A1 Uriarte Isacelaya, Esther
A1 Tomero Muriel, Eva
A1 Salman Monte, Tarek C.
A1 Carrión Barberà, Irene
A1 Galindo, Maria
A1 Rodríguez Almaraz, Esther M
A1 Jimenez Otero, Norman
A1 Inês, Luis
A1 Pego Reigosa, José María
K1 3205.09 Reumatología
K1 2412 Inmunología
AB ObjectivesTo apply the lupus low disease activity state (LLDAS) definition within a large cohort of patients and to assess the agreement between the LLDAS and the physician’s subjective evaluation of lupus activity.MethodsWe conducted a cross-sectional analysis of a prospective multicentre study of SLE patients. We applied the LLDAS and assessed whether there was agreement with the clinical status according to the physician’s opinion.ResultsA total of 508 patients [92% women; mean age 50.4 years (s.d. 3.7)] were recruited and 304 (62.7%) patients were in the LLDAS. According to physician assessment, 430 (86.1%) patients were classified as remission or low activity. Overall agreement between both evaluations was 71.4% (95% CI: 70.1, 70.5) with a Cohen’s κ of 0.3 [interquartile range (IQR) 0.22–0.37]. Most cases (96.1%) in the LLDAS were classified as remission or low activity by the expert. Of the patients who did not fulfil the LLDAS, 126 (70.4%) were classified as having remission/low disease activity. The main reasons for these discrepancies were the presence of new manifestations compared with the previous visit and a SLEDAI 2K score >4, mainly based on serological activity.ConclusionsAlmost two-thirds of SLE patients were in the LLDAS. There was a fair correlation between the LLDAS and the physician’s evaluation. This agreement improves for patients fulfilling the LLDAS criteria. The discordance between both at defining lupus low activity, the demonstrated association of the LLDAS with better outcomes and the fact that the LLDAS is more stringent than the physician’s opinion imply that we should use the LLDAS as a treat-to-target goal
PB Rheumatology
SN 14620324
YR 2023
FD 2023-03-01
LK http://hdl.handle.net/11093/4997
UL http://hdl.handle.net/11093/4997
LA eng
NO Rheumatology, 62(3): 1162-1169 (2022)
NO ISCIII-Fondo Europeo de Desarrollo | Ref. PI17/01366
DS Investigo
RD 15-mar-2025