RT Journal Article
T1 Fatty acids of different nature differentially modulate feed intake in rainbow trout
A1 Calo Rodríguez, Jessica
A1 Conde Sieira, Marta
A1 Comesaña Fernández, Sara
A1 Soengas Fernández, José Luis
A1 Blanco Imperiali, Ayelén Melisa
K1 2401.13 Fisiología Animal
K1 3105.07 Hábitos de Alimentación
K1 3105 Peces y Fauna Silvestre
AB Feed intake is subjected to a complex regulation involving a plethora of signals, among which nutrients stand as one of the most important. In mammals, the gastrointestinal tract is able to sense nutrients in the lumen, and respond with the release of signaling molecules that ultimately modulate brain circuits governing appetite, resulting in decreased/increased feeding. Whether equivalent mechanisms operate in fish remains unknown. In a recent study, we described that the gastrointestinal tract of rainbow trout contains several sensors for free fatty acids (FAs), and that the luminal presence of FAs of different length and degree of unsaturation modulates the levels of key gastrointestinal hormones involved in feed intake regulation. In this study, our aim was to characterize the impact of such a luminal presence of FAs on brain appetite-regulatory centers, as well as its effects on rainbow trout feed intake. Major results from this study demonstrated that: (i) FAs of different length and degree of unsaturation [medium-chain (MCFAs, octanoate), long-chain (LCFAs, oleate), long-chain polyunsaturated (PUFA, α-linolenate), and short-chain (SCFA, butyrate) FAs] differentially modulate feed intake levels when administered intragastrically, (ii) intragastrically-administered FAs modulate the phosphorylation status of appetite-related transcription factors, as well as mRNA levels of key appetite-regulating neuropeptides, in the hypothalamus and/or telencephalon, (iii) luminal presence of FAs results in changes in the central abundance of mRNAs encoding gastrointestinal hormone receptors, and (vi) luminal FA-derived central changes in neuropeptide mRNAs are not observed (or are lessened) in vagotomized fish. Together, these results provide comprehensive evidence in favor of a gut-brain axis in fish. In addition, we observed different responses in terms of feed intake regulation depending on the type of fatty acid administered into the lumen, which is very relevant for aquaculture considering differences in fatty acid composition in aquafeeds
PB Aquaculture
SN 00448486
YR 2023
FD 2023-01-30
LK http://hdl.handle.net/11093/4247
UL http://hdl.handle.net/11093/4247
LA eng
NO Aquaculture, 563, 738961 (2023)
NO Agencia Estatal de Investigación | Ref. PID2019-103969RB-C31
DS Investigo
RD 15-ene-2025