RT Journal Article
T1 Magnetically propelled chained nanocomposites for biologically relevant media exploration
A1 Ramos Docampo, Miguel Alexandre
A1 Hurtado, Pablo
A1 Davila Ibañez, Ana Belen
A1 Piñeiro, Roberto
A1 López Fanarraga, Mónica
A1 Salgueiriño Maceira, Verónica
K1 2210 Química Física
AB Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.
PB Journal of Colloid and Interface Science
SN 00219797
YR 2023
FD 2023-01
LK http://hdl.handle.net/11093/4243
UL http://hdl.handle.net/11093/4243
LA eng
NO Journal of Colloid and Interface Science, 629, 287-296 (2023)
NO Financiado para publicación en acceso aberto: Universidade de Vigo/CISUG
NO Xunta de Galicia | Ref. ED481A/322
DS Investigo
RD 25-ene-2025