RT Journal Article
T1 Identification of genomic regions regulating sex determination in Atlantic salmon using high density SNP data
A1 Gabián Álvarez, María
A1 Morán Martínez, Maria Paloma
A1 Fernández Ávila, Ana Isabel
A1 Villanueva, Beatriz
A1 Chtioui, Amel
A1 Kent, Matthew P
A1 Covelo Soto, Lara
A1 Fernández Muñoz, Almudena
A1 Saura Álvarez, María
K1 2409.03 Genética de Poblaciones
K1 2401.19 Zoología Marina
K1 2409.90 Citogenética Animal
AB Background: A complete understanding of the genetic basis for sexual determination and differentiation isnecessary in order to implement efficient breeding schemes at early stages of development. Atlantic salmonbelongs to the family Salmonidae of fishes and represents a species of great commercial value. Although thespecies is assumed to be male heterogametic with XY sex determination, the precise genetic basis of sexualdevelopment remains unclear. The complexity is likely associated to the relatively recent salmonid specific wholegenome duplication that may be responsible for certain genome instability. This instability together with thecapacity of the sex-determining gene to move across the genome as reported by previous studies, may explainthat sexual development genes are not circumscribed to the same chromosomes in all members of the species. Inthis study, we have used a 220 K SNP panel developed for Atlantic salmon to identify the chromosomes explainingthe highest proportion of the genetic variance for sex as well as candidate regions and genes associated to sexualdevelopment in this species.Results: Results from regional heritability analysis showed that the chromosomes explaining the highest proportionof variance in these populations were Ssa02 (heritability = 0.42, SE = 0.12) and Ssa21 (heritability = 0.26, SE = 0.11).After pruning by linkage disequilibrium, genome-wide association analyses revealed 114 SNPs that weresignificantly associated with sex, being Ssa02 the chromosome containing a greatest number of regions. Closeexamination of the candidate regions evidenced important genes related to sex in other species of ClassActinopterygii, including SDY, genes from family SOX, RSPO1, ESR1, U2AF2A, LMO7, GNRH-R, DND and FIGLA.Conclusions: The combined results from regional heritability analysis and genome-wide association have providednew advances in the knowledge of the genetic regulation of sex determination in Atlantic salmon, supporting thatSsa02 is the candidate chromosome for sex in this species and suggesting an alternative population lineage inSpanish wild populations according to the results from Ssa21.
PB BMC Genomics
SN 14712164
YR 2019
FD 2019-10-22
LK http://hdl.handle.net/11093/4157
UL http://hdl.handle.net/11093/4157
LA eng
NO BMC Genomics, 20(1): 764 (2019)
NO Ministerio de Economía y Competitividad | Ref. RZ2012–00011-C02–00
DS Investigo
RD 08-feb-2025