RT Journal Article
T1 Anti-inflammatory effects of GLP-1 receptor activation in the brain in neurodegenerative diseases
A1 Diz Chaves, Yolanda Maria
A1 Mastoor, Zainab
A1 Spuch Calvar, Carlos
A1 González Matías, Lucas Carmelo
A1 Mallo Ferrer, Federico
K1 3205.07 Neurología
K1 3209 Farmacología
K1 2302 Bioquímica
K1 2411.11 Neurofisiología
AB The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.
PB International Journal of Molecular Sciences
SN 14220067
YR 2022
FD 2022-08-24
LK http://hdl.handle.net/11093/3787
UL http://hdl.handle.net/11093/3787
LA eng
NO International Journal of Molecular Sciences, 23(17): 9583 (2022)
NO European Union | Ref. H2020-BBIJTI- 2019-887259
DS Investigo
RD 09-dic-2024