RT Journal Article
T1 An expanded surface-enhanced raman scattering tags library by combinatorial rncapsulation of reporter molecules in metal nanoshells
A1 Rodal Cedeira, Sergio
A1 Vázquez Arias, Alba
A1 Bodelón González, Gustavo
A1 Skorikov, Alexander
A1 Núñez Sánchez, Sara
A1 Laporta, Andrea
A1 Polavarapu , Lakshminarayana
A1 Bals, Sara
A1 Liz Marzán, Luis Manuel
A1 Pérez Juste, Jorge
A1 Pastoriza Santos, Isabel
K1 2210 Química Física
AB Raman-encoded gold nanoparticles (NPs) have been widely employed as photostable multifunctional probes for sensing, bioimaging, multiplex diagnostics, and surfaceenhanced Raman scattering (SERS)-guided tumor therapy. We report a strategy toward obtaining a particularly large library of Au nanocapsules encoded with Raman codes defined by the combination of different thiol-free Raman reporters, encapsulated at defined molar ratios. The fabrication of SERS tags with tailored size and predefined codes is based on the in situ incorporation of Raman reporter molecules inside Au nanocapsules during their formation "via" galvanic replacement coupled to seeded growth on Ag NPs. The hole-free closedshell structure of the nanocapsules is confirmed by electron tomography. The unusually wide encoding possibilities of the obtained SERS tags are investigated by means of either wavenumber-based encoding or Raman frequency combined with signal intensity, leading to an outstanding performance as exemplified by 26 and 54 different codes, respectively. We additionally demonstrate that encoded nanocapsules can be readily bioconjugated with antibodies for applications such as SERS-based targeted cell imaging and phenotyping.
PB ACS Nano
SN 19360851
YR 2020
FD 2020-09-01
LK http://hdl.handle.net/11093/3667
UL http://hdl.handle.net/11093/3667
LA eng
NO ACS Nano, 14(11): 14655-14664 (2020)
NO Ministerio de Ciencia, Innovación y Universidades | Ref. MDM-2017-0720
DS Investigo
RD 23-ene-2025