RT Journal Article
T1 Recent advances in microfluidic platform for physical and immunological detection and capture of circulating tumor cells
A1 Bhat, Mahesh Padmalaya
A1 Thendral, Venkatachalam
A1 Uthappa, Uluvangada Thammaiah
A1 Lee, Kyeong-Hwan
A1 Kigga, Madhuprasad
A1 Altalhi, Tariq
A1 Kurkuri, Mahaveer D.
A1 Kant , Krishna
K1 3207.03 Carcinogénesis
K1 2407 Biología Celular
K1 2302 Bioquímica
AB CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous benefits in cancer diagnosis and treatment. In general, various approaches are being used to separate malignant cells, including immunomagnets, macroscale filters, centrifuges, dielectrophoresis, and immunological approaches. These procedures, on the other hand, are time-consuming and necessitate multiple high-level operational protocols. In addition, considering their low efficiency and throughput, the processes of capturing and isolating CTCs face tremendous challenges. Meanwhile, recent advances in microfluidic devices promise unprecedented advantages for capturing and isolating CTCs with greater efficiency, sensitivity, selectivity and accuracy. In this regard, this review article focuses primarily on the various fabrication methodologies involved in microfluidic devices and techniques specifically used to capture and isolate CTCs using various physical and biological methods as well as their conceptual ideas, advantages and disadvantages.
PB Biosensors
SN 20796374
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/11093/3578
UL http://hdl.handle.net/11093/3578
LA eng
NO Biosensors, 12(4): 220 (2022)
NO Department of Science & Technology | Ref. TDP/BDTD/32/2019
DS Investigo
RD 23-ene-2025