RT Journal Article
T1 Anti-depressant properties of crocin molecules in saffron
A1 Siddiqui, Shahida Anusha
A1 Ali Redha, Ali
A1 Snoeck, Edgar Remmet
A1 Singh, Shubhra
A1 Simal Gándara, Jesús
A1 Ibrahim, Salam A.
A1 Jafari, Seid Mahdi
K1 5101.13 Medicina Tradicional
K1 3209.04 Medicamentos Naturales
AB Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome.
PB Molecules
SN 14203049
YR 2022
FD 2022-03-23
LK http://hdl.handle.net/11093/3538
UL http://hdl.handle.net/11093/3538
LA eng
NO Molecules, 27(7): 2076 (2022)
NO United States Department of Agriculture | Ref. 2020-38821-31113
DS Investigo
RD 13-dic-2024