RT Journal Article
T1 HLA-DRB1*07:01 and *08:02 alleles confer a protective effect against ACPA-positive rheumatoid arthritis in a Latin American admixed population
A1 Castro Santos, Patricia
A1 Olloquequi, Jordi
A1 Verdugo, Ricardo A.
A1 Gutiérrez, Miguel A.
A1 Pinochet, Carmen
A1 Quiñones, Luis A.
A1 Díaz Peña, Roberto
K1 3205.09 Reumatología
K1 2409 Genética
K1 2409.03 Genética de Poblaciones
AB HLA-DRB1 shared epitope (SE) alleles are important genetic contributors for the risk of developing anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis (RA), particularly in Caucasians. We aimed to analyze the contribution of HLA-DRB1 alleles and single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) region to the susceptibility to develop ACPA-positive RA in a Latin American (LA) population with admixed ancestry. A total of 289 ACPA-positive RA patients and 510 controls were enrolled in this study. The presence of HLA-DRB1*04:01, *09:01 and *10:01 was increased in ACPA-positive RA patients compared with healthy controls (p < 0.0001, p < 0.001 and p < 0.01, respectively), whereas DRB1*07:01 and *08:02 was associated with a decreased risk of ACPA-positive RA (p < 0.001 and p < 0.01, respectively). These results showed a strong correlation with estimates from studies in Asians but not in Caucasian populations. The present study describes the protective effects of the HLA-DRB1*07:01 and *08:02 alleles in ACPA-positive RA patients in a LA population for the first time. Identifying relationships between HLA-DRB1 alleles and RA is important for identifying disease associations in different ethnic groups in order to reach a better understanding of RA worldwide.
PB Biology
SN 20797737
YR 2020
FD 2020-12-14
LK http://hdl.handle.net/11093/3318
UL http://hdl.handle.net/11093/3318
LA eng
NO Biology, 9(12): 467 (2020)
NO Fondecyt (Chile) | Ref. n. 11130198
DS Investigo
RD 07-feb-2025