RT Journal Article
T1 The dopaminergic control of movement-evolutionary considerations
A1 Pérez Fernández, Juan
A1 Barandela, Marta
A1 Jiménez López, Cecilia
K1 2490 Neurociencias
K1 3207.11 Neuropatología
K1 2302 Bioquímica
AB Dopamine is likely the most studied modulatory neurotransmitter, in great part due to characteristic motor deficits in Parkinson’s disease that arise after the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). The SNc, together with the ventral tegmental area (VTA), play a key role modulating motor responses through the basal ganglia. In contrast to the large amount of existing literature addressing the mammalian dopaminergic system, comparatively little is known in other vertebrate groups. However, in the last several years, numerous studies have been carried out in basal vertebrates, allowing a better understanding of the evolution of the dopaminergic system, especially the SNc/VTA. We provide an overview of existing research in basal vertebrates, mainly focusing on lampreys, belonging to the oldest group of extant vertebrates. The lamprey dopaminergic system and its role in modulating motor responses have been characterized in significant detail, both anatomically and functionally, providing the basis for understanding the evolution of the SNc/VTA in vertebrates. When considered alongside results from other early vertebrates, data in lampreys show that the key role of the SNc/VTA dopaminergic neurons modulating motor responses through the basal ganglia was already well developed early in vertebrate evolution.
PB International Journal of Molecular Sciences
SN 14220067
YR 2021
FD 2021-10-19
LK http://hdl.handle.net/11093/2603
UL http://hdl.handle.net/11093/2603
LA eng
NO International Journal of Molecular Sciences, 22(20): 11284 (2021)
NO Xunta de Galicia | Ref. ED431B 2021/04
DS Investigo
RD 11-dic-2024