RT Dissertation/Thesis
T1 Development and optimization of LC-MS for the identification and confirmation of ciguatoxins
T2 Desarrollo y optimización de LC-MS para la identificación y confirmación de ciguatoxinas
A1 Estevez Bastos, Pablo
K1 2301 Química Analítica
K1 2301.03 Análisis Cromatográfico
K1 2301.10 Espectroscopia de Masas
AB CFP (Ciguatera Fish Poissoning) is a disease associated with the appearance of gastrointestinal and neurological symptoms caused by the consumption of fish contaminated with ciguatoxin (CTX), whose precursors are produced by benthic dinoflagellates of the genus Gambierdiscus. Although these CTXs producing species are endemic to coral reefs in the Pacific, Indian and Caribbean marine regions, cases of CFP have recently been confirmed in the Canary Islands and other European regions, in addition to the identification of various species of Gambierdiscus in the North Atlantic, representing an emerging problem for public health in Europe.The lipophilicity of the mentioned toxins coupled with the complexity of the matrix in which they are present necessitates the optimization of efficient extraction and purification steps for the removal of endogenous matrix compounds which would affect the efficiency of the analysis.The PhD thesis will focus on the design and evaluation of effective sample preparation protocols for the analysis of ciguatoxins in contaminated fish.
YR 2021
FD 2021-06-11
LK http://hdl.handle.net/11093/2247
UL http://hdl.handle.net/11093/2247
LA eng
DS Investigo
RD 12-dic-2024