RT Journal Article
T1 Apo-14´-Carotenoic acid is a novel endogenous and bioactive apo-carotenoid
A1 Aydemir, Gamze
A1 Dominguez Seoane, Marta
A1 Rodríguez de Lera, Ángel
A1 Mihaly, Johanna
A1 Törőcsik, Dániel
A1 Rühl, Ralph
K1 2306 Química Orgánica
AB Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15´-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14´-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response element (RARE)-mediated signalling in DR5/RARE-reporter mice and potently increase retinoid-reporter target gene expression in ATA14CA-supplemented mice and treated MM6 cells. Further metabolism to all-trans-13,14-dihydroretinoic acid (ATDHRA) may be the key for its potent effects on retinoid target gene activation in ATA14CA-treated MM6 cells and in liver of supplemented mice. We conclude that besides RAs, there are alternative ways to activate RAR-response pathways in the mammalian organism. ATA14CA alone and in combination with its metabolite ATDHRA may be an alternative pathway for potent RAR-mediated signalling.
PB Nutrients
SN 20726643
YR 2019
FD 2019-09-04
LK http://hdl.handle.net/11093/2131
UL http://hdl.handle.net/11093/2131
LA eng
NO Nutrients, 11(9): 2084 (2019)
NO Ministerio de Economía y Competitividad (España) | Ref. SAF2016-77620-R-FEDER
DS Investigo
RD 18-ene-2025