RT Journal Article
T1 Unravelling the biological activities of the Byttneria pilosa leaves using experimental and computational approaches
A1 Jyoti, Mifta Ahmed
A1 Barua, Niloy
A1 Hossain, Mohammad Shafaet
A1 Hoque, Muminul
A1 Bristy, Tahmina Akter
A1 Mahmud, Shabnur
A1 Kamruzzaman, Kamruzzaman
A1 Adnan, Md.
A1 Chy, Md. Nazim Uddin
A1 Paul, Arkajyoti
A1 Hossain, Mir Ezharul
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 3209.04 Medicamentos Naturales
K1 5101.13 Medicina Tradicional
K1 3209.07 Fitofármacos
AB Byttneria pilosa is locally known as Harijora, and used by the native hill-tract people of Bangladesh for the treatment of rheumatalgia, snake bite, syphilis, fractured bones, elephantiasis and an antidote for poisoning. The present study was carried out to determine the possible anti-inflammatory, analgesic, neuropharmacological and anti-diarrhoeal activity of the methanol extract of B. pilosa leaves (MEBPL) through in vitro, in vivo and in silico approaches. In the anti-inflammatory study, evaluated by membrane stabilizing and protein denaturation methods, MEBPL showed a significant and dose dependent inhibition. The analgesic effect of MEBPL tested by inducing acetic acid and formalin revealed significant inhibition of pain in both tests. During the anxiolytic evaluation, the extract exhibited a significant and dose-dependent reduction of anxiety-like behaviour in mice. Similarly, mice treated with MEBPL demonstrated dose-dependent reduction in locomotion effect in the open field test and increased sedative effect in the thiopental sodium induced sleeping test. MEBPL also showed good anti-diarrheal activity in both castor oil induced diarrheal and intestinal motility tests. Besides, a previously isolated compound (beta-sitosterol) exhibited good binding affinity in docking and drug-likeliness properties in ADME/T studies. Overall, B. pilosa is a biologically active plant and could be a potential source of drug leads, which warrants further advanced study.
PB Molecules
SN 14203049
YR 2020
FD 2020-10-15
LK http://hdl.handle.net/11093/1805
UL http://hdl.handle.net/11093/1805
LA eng
NO Molecules, 25(20): 4737 (2020)
DS Investigo
RD 10-dic-2024