RT Journal Article
T1 Biochemical and computational approach of selected phytocompounds from Tinospora crispa in the management of COVID-19
A1 Rakib, Ahmed
A1 Paul, Arkajyoti
A1 Chy, Md. Nazim Uddin
A1 Sami, Saad Ahmed
A1 Baral, Sumit Kumar
A1 Majumder, Mohuya
A1 Tareq, Abu Montakim
A1 Amin, Mohammad Nurul
A1 Shahriar, Asif
A1 Uddin, Md. Zia
A1 Dutta, Mycal
A1 Tallei, Trina Ekawati
A1 Emran, Talha Bin
A1 Simal Gándara, Jesús
K1 2302 Bioquímica
K1 3207.10 Inmunopatología
K1 2420 Virología
AB A pandemic caused by the novel coronavirus (SARS-CoV-2 or COVID-19) began in December 2019 in Wuhan, China, and the number of newly reported cases continues to increase. More than 19.7 million cases have been reported globally and about 728,000 have died as of this writing (10 August 2020). Recently, it has been confirmed that the SARS-CoV-2 main protease (Mpro) enzyme is responsible not only for viral reproduction but also impedes host immune responses. The Mpro provides a highly favorable pharmacological target for the discovery and design of inhibitors. Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. Therefore, herein, we analyzed the bioactive phytocompounds isolated by gas chromatography–mass spectroscopy (GC-MS) from Tinospora crispa as potential COVID-19 Mpro inhibitors, using molecular docking study. Our analyses unveiled that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules, with three of them exerting biological activity and warranting further optimization and drug development to combat COVID-19.
PB Molecules
SN 14203049
YR 2020
FD 2020-08-28
LK http://hdl.handle.net/11093/1608
UL http://hdl.handle.net/11093/1608
LA eng
NO Molecules, 25(17): 3936 (2020)
DS Investigo
RD 15-mar-2025