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dc.contributor.authorGómez González, Borja
dc.contributor.authorBasílio, Nuno
dc.contributor.authorVaz Araujo, Belén 
dc.contributor.authorPerez Lorenzo, Moisés 
dc.contributor.authorGarcía Río, Luis
dc.date.accessioned2024-10-04T09:01:51Z
dc.date.available2024-10-04T09:01:51Z
dc.date.issued2024-02-12
dc.identifier.citationAngewandte Chemie International Edition, 63(7): e202317553 (2024)spa
dc.identifier.issn14337851
dc.identifier.issn15213773
dc.identifier.urihttp://hdl.handle.net/11093/7586
dc.description.abstractThe determination of binding constants is a key matter in evaluating the strength of host–guest interactions. However, the profound impact of self‐ion pairing on this parameter is often underrated in aqueous solution, leading in some cases to a misinterpretation of the true potential of supramolecular assemblies. In the present study, we aim to shed further light on this critical factor by exploring the concentration‐dependent behavior of a multicharged pillararene in water. Our observations reveal an extraordinary 1‐million‐fold variability in the affinity of this macrocycle toward a given anion, showcasing the highly dynamic character of electrostatic interactions. We argue that these findings bring to the forefront the inherent determinism that underlies the estimation of affinity constants, a factor profoundly shaped by both the sensitivity of the instrumental technique in use and the intricacies of the experimental design itself. In terms of applications, these results may provide the opportunity to optimize the operational concentrations of multicharged hosts in different scenarios, aiming to achieve their maximum efficiency based on the intended application. Unlocking the potential of this hidden variability may pave the way for the creation of novel molecular materials with advanced functionalities.en
dc.description.sponsorshipAgencia Estatal de Investigación | Ref. PID2020-113704RB-I00spa
dc.description.sponsorshipXunta de Galicia | Ref. ED431G 2019/06spa
dc.description.sponsorshipXunta de Galicia | Ref. ED431C 2022/24spa
dc.description.sponsorshipXunta de Galicia | Ref. ED431C 2021/45spa
dc.description.sponsorshipUniversidade de Vigo/CISUGspa
dc.language.isoengspa
dc.publisherAngewandte Chemie International Editionspa
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113704RB-I00/ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDelving into the variability of supramolecular affinity: self‐ion pairing as a central player in aqueous host‐guest chemistryen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.1002/anie.202317553
dc.identifier.editorhttps://onlinelibrary.wiley.com/doi/10.1002/anie.202317553spa
dc.publisher.departamentoQuímica orgánicaspa
dc.publisher.departamentoQuímica Físicaspa
dc.publisher.grupoinvestigacionQuímica Orgánica 1spa
dc.publisher.grupoinvestigacionTEAM NANO TECH (Grupo de Nanotecnoloxía)spa
dc.subject.unesco2304 Química Macromolecularspa
dc.date.updated2024-10-04T08:58:27Z
dc.computerCitationpub_title=Angewandte Chemie International Edition|volume=63|journal_number=7|start_pag=e202317553|end_pag=spa


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