dc.contributor.author | Gómez González, Borja | |
dc.contributor.author | Basílio, Nuno | |
dc.contributor.author | Vaz Araujo, Belén | |
dc.contributor.author | Perez Lorenzo, Moisés | |
dc.contributor.author | García Río, Luis | |
dc.date.accessioned | 2024-10-04T09:01:51Z | |
dc.date.available | 2024-10-04T09:01:51Z | |
dc.date.issued | 2024-02-12 | |
dc.identifier.citation | Angewandte Chemie International Edition, 63(7): e202317553 (2024) | spa |
dc.identifier.issn | 14337851 | |
dc.identifier.issn | 15213773 | |
dc.identifier.uri | http://hdl.handle.net/11093/7586 | |
dc.description.abstract | The determination of binding constants is a key matter in evaluating the strength of host–guest interactions. However, the profound impact of self‐ion pairing on this parameter is often underrated in aqueous solution, leading in some cases to a misinterpretation of the true potential of supramolecular assemblies. In the present study, we aim to shed further light on this critical factor by exploring the concentration‐dependent behavior of a multicharged pillararene in water. Our observations reveal an extraordinary 1‐million‐fold variability in the affinity of this macrocycle toward a given anion, showcasing the highly dynamic character of electrostatic interactions. We argue that these findings bring to the forefront the inherent determinism that underlies the estimation of affinity constants, a factor profoundly shaped by both the sensitivity of the instrumental technique in use and the intricacies of the experimental design itself. In terms of applications, these results may provide the opportunity to optimize the operational concentrations of multicharged hosts in different scenarios, aiming to achieve their maximum efficiency based on the intended application. Unlocking the potential of this hidden variability may pave the way for the creation of novel molecular materials with advanced functionalities. | en |
dc.description.sponsorship | Agencia Estatal de Investigación | Ref. PID2020-113704RB-I00 | spa |
dc.description.sponsorship | Xunta de Galicia | Ref. ED431G 2019/06 | spa |
dc.description.sponsorship | Xunta de Galicia | Ref. ED431C 2022/24 | spa |
dc.description.sponsorship | Xunta de Galicia | Ref. ED431C 2021/45 | spa |
dc.description.sponsorship | Universidade de Vigo/CISUG | spa |
dc.language.iso | eng | spa |
dc.publisher | Angewandte Chemie International Edition | spa |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113704RB-I00/ES | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Delving into the variability of supramolecular affinity: self‐ion pairing as a central player in aqueous host‐guest chemistry | en |
dc.type | article | spa |
dc.rights.accessRights | openAccess | spa |
dc.identifier.doi | 10.1002/anie.202317553 | |
dc.identifier.editor | https://onlinelibrary.wiley.com/doi/10.1002/anie.202317553 | spa |
dc.publisher.departamento | Química orgánica | spa |
dc.publisher.departamento | Química Física | spa |
dc.publisher.grupoinvestigacion | Química Orgánica 1 | spa |
dc.publisher.grupoinvestigacion | TEAM NANO TECH (Grupo de Nanotecnoloxía) | spa |
dc.subject.unesco | 2304 Química Macromolecular | spa |
dc.date.updated | 2024-10-04T08:58:27Z | |
dc.computerCitation | pub_title=Angewandte Chemie International Edition|volume=63|journal_number=7|start_pag=e202317553|end_pag= | spa |