Cannabidiol-loaded nanocarriers and their therapeutic applications

Assadpour, Elham; Rezaei, Atefe; Das, Sabya Sachi; Krishna Rao, Balaga Venkata; Singh, Sandeep Kumar; Kharazmi, Mohammad Saeed; Jha, Niraj Kumar; Jha, Saurabh Kumar; Prieto Lage, Miguel Ángel; Jafari, Seid Mahdi

doi:10.3390/ph16040487

Assadpour, Elham; Rezaei, Atefe; Das, Sabya Sachi; Krishna Rao, Balaga Venkata; Singh, Sandeep Kumar; Kharazmi, Mohammad Saeed; Jha, Niraj Kumar; Jha, Saurabh Kumar; Prieto Lage, Miguel Ángel

; Jafari, Seid Mahdi

DATE: 2023-03-24

UNIVERSAL IDENTIFIER: http://hdl.handle.net/11093/4755

EDITED VERSION: https://www.mdpi.com/1424-8247/16/4/487

UNESCO SUBJECT: 3209 Farmacología ; 32 Ciencias Médicas ; 2302.22 Farmacología Molecular ; 2302 Bioquímica

DOCUMENT TYPE: article

ABSTRACT

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

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