dc.contributor.author | Castro Santos, Patricia | |
dc.contributor.author | Olloquequi, Jordi | |
dc.contributor.author | Verdugo, Ricardo A. | |
dc.contributor.author | Gutiérrez, Miguel A. | |
dc.contributor.author | Pinochet, Carmen | |
dc.contributor.author | Quiñones, Luis A. | |
dc.contributor.author | Díaz Peña, Roberto | |
dc.date.accessioned | 2022-03-23T11:43:17Z | |
dc.date.available | 2022-03-23T11:43:17Z | |
dc.date.issued | 2020-12-14 | |
dc.identifier.citation | Biology, 9(12): 467 (2020) | spa |
dc.identifier.issn | 20797737 | |
dc.identifier.uri | http://hdl.handle.net/11093/3318 | |
dc.description.abstract | HLA-DRB1 shared epitope (SE) alleles are important genetic contributors for the risk of developing anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis (RA), particularly in Caucasians. We aimed to analyze the contribution of HLA-DRB1 alleles and single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) region to the susceptibility to develop ACPA-positive RA in a Latin American (LA) population with admixed ancestry. A total of 289 ACPA-positive RA patients and 510 controls were enrolled in this study. The presence of HLA-DRB1*04:01, *09:01 and *10:01 was increased in ACPA-positive RA patients compared with healthy controls (p < 0.0001, p < 0.001 and p < 0.01, respectively), whereas DRB1*07:01 and *08:02 was associated with a decreased risk of ACPA-positive RA (p < 0.001 and p < 0.01, respectively). These results showed a strong correlation with estimates from studies in Asians but not in Caucasian populations. The present study describes the protective effects of the HLA-DRB1*07:01 and *08:02 alleles in ACPA-positive RA patients in a LA population for the first time. Identifying relationships between HLA-DRB1 alleles and RA is important for identifying disease associations in different ethnic groups in order to reach a better understanding of RA worldwide. | en |
dc.description.sponsorship | Fondecyt (Chile) | Ref. n. 11130198 | spa |
dc.language.iso | eng | spa |
dc.publisher | Biology | spa |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | HLA-DRB1*07:01 and *08:02 alleles confer a protective effect against ACPA-positive rheumatoid arthritis in a Latin American admixed population | en |
dc.type | article | spa |
dc.rights.accessRights | openAccess | spa |
dc.identifier.doi | 10.3390/biology9120467 | |
dc.identifier.editor | https://www.mdpi.com/2079-7737/9/12/467 | spa |
dc.subject.unesco | 3205.09 Reumatología | spa |
dc.subject.unesco | 2409 Genética | spa |
dc.subject.unesco | 2409.03 Genética de Poblaciones | spa |
dc.date.updated | 2022-03-23T08:58:27Z | |
dc.computerCitation | pub_title=Biology|volume=9|journal_number=12|start_pag=467|end_pag= | spa |