Show simple item record

dc.contributor.authorCastro Santos, Patricia 
dc.contributor.authorOlloquequi, Jordi
dc.contributor.authorVerdugo, Ricardo A.
dc.contributor.authorGutiérrez, Miguel A.
dc.contributor.authorPinochet, Carmen
dc.contributor.authorQuiñones, Luis A.
dc.contributor.authorDíaz Peña, Roberto
dc.date.accessioned2022-03-23T11:43:17Z
dc.date.available2022-03-23T11:43:17Z
dc.date.issued2020-12-14
dc.identifier.citationBiology, 9(12): 467 (2020)spa
dc.identifier.issn20797737
dc.identifier.urihttp://hdl.handle.net/11093/3318
dc.description.abstractHLA-DRB1 shared epitope (SE) alleles are important genetic contributors for the risk of developing anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis (RA), particularly in Caucasians. We aimed to analyze the contribution of HLA-DRB1 alleles and single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) region to the susceptibility to develop ACPA-positive RA in a Latin American (LA) population with admixed ancestry. A total of 289 ACPA-positive RA patients and 510 controls were enrolled in this study. The presence of HLA-DRB1*04:01, *09:01 and *10:01 was increased in ACPA-positive RA patients compared with healthy controls (p < 0.0001, p < 0.001 and p < 0.01, respectively), whereas DRB1*07:01 and *08:02 was associated with a decreased risk of ACPA-positive RA (p < 0.001 and p < 0.01, respectively). These results showed a strong correlation with estimates from studies in Asians but not in Caucasian populations. The present study describes the protective effects of the HLA-DRB1*07:01 and *08:02 alleles in ACPA-positive RA patients in a LA population for the first time. Identifying relationships between HLA-DRB1 alleles and RA is important for identifying disease associations in different ethnic groups in order to reach a better understanding of RA worldwide.en
dc.description.sponsorshipFondecyt (Chile) | Ref. n. 11130198spa
dc.language.isoengspa
dc.publisherBiologyspa
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHLA-DRB1*07:01 and *08:02 alleles confer a protective effect against ACPA-positive rheumatoid arthritis in a Latin American admixed populationen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/biology9120467
dc.identifier.editorhttps://www.mdpi.com/2079-7737/9/12/467spa
dc.subject.unesco3205.09 Reumatologíaspa
dc.subject.unesco2409 Genéticaspa
dc.subject.unesco2409.03 Genética de Poblacionesspa
dc.date.updated2022-03-23T08:58:27Z
dc.computerCitationpub_title=Biology|volume=9|journal_number=12|start_pag=467|end_pag=spa


Files in this item

[PDF]

    Show simple item record

    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International