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dc.contributor.authorCunha, Joana T.
dc.contributor.authorRomaní Pérez, Aloia
dc.contributor.authorDomingues, Lucília
dc.date.accessioned2022-03-22T11:06:33Z
dc.date.available2022-03-22T11:06:33Z
dc.date.issued2022-02-08
dc.identifier.citationCatalysts, 12(2): 202 (2022)spa
dc.identifier.issn20734344
dc.identifier.urihttp://hdl.handle.net/11093/3309
dc.description.abstractThe implementation of cost-effective and sustainable biorefineries to substitute the petroleum-based economy is dependent on coupling the production of bioenergy with high-value chemicals. For this purpose, the US Department of Energy identified a group of key target compounds to be produced from renewable biomass. Among them, 5-hydroxymethylfurfural (HMF) can be obtained by dehydration of the hexoses present in biomass and is an extremely versatile molecule that can be further converted into a wide range of higher value compounds. HMF derivatives include 2,5-bis(hydroxymethyl)furan (BHMF), 5-hydroxymethyl-furan-2-carboxylic acid (HMFCA), 2,5-diformylfuran (DFF), 5-formyl-2-furancarboxylic acid (FFCA) and 2,5-furandicarboxylic acid (FDCA), all presenting valuable applications, in polymers, bioplastics and pharmaceuticals. Biocatalysis conversion of HMF into its derivatives emerges as a green alternative, taking into account the high selectivity of enzymes and the mild reaction conditions used. Considering these factors, this work reviews the use of microorganisms as whole-cell biocatalysts for the production of HMF derivatives. In the last years, a large number of whole-cell biocatalysts have been discovered and developed for HMF conversion into BHMF, FDCA and HMFCA, however there are no reports on microbial production of DFF and FFCA. While the production of BHMF and HMFCA mainly relies on wild type microorganisms, FDCA production, which requires multiple bioconversion steps from HMF, is strongly dependent on genetic engineering strategies. Together, the information gathered supports the possibility for the development of cell factories to produce high-value compounds, envisioning economical viable biorefineries.en
dc.description.sponsorshipFundação para a Ciência e Tecnologia | Ref. UIDB/04469/2020spa
dc.description.sponsorshipMinisterio de Ciencia y Innovación | Ref. RYC2020-030690-Ispa
dc.language.isoengspa
dc.publisherCatalystsspa
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2020-030690-I/ES
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleWhole cell biocatalysis of 5-hydroxymethylfurfural for sustainable biorefineriesen
dc.typearticlespa
dc.rights.accessRightsopenAccessspa
dc.identifier.doi10.3390/catal12020202
dc.identifier.editorhttps://www.mdpi.com/2073-4344/12/2/202spa
dc.publisher.departamentoEnxeñaría químicaspa
dc.publisher.grupoinvestigacionPranta, Solo e Aproveitamento de Subproductosspa
dc.subject.unesco3302.90 Ingeniería Bioquímicaspa
dc.subject.unesco3303.03 Procesos Químicosspa
dc.subject.unesco3303 Ingeniería y Tecnología Químicasspa
dc.date.updated2022-03-22T08:41:16Z
dc.computerCitationpub_title=Catalysts|volume=12|journal_number=2|start_pag=202|end_pag=spa


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    Attribution 4.0 International
    Except where otherwise noted, this item's license is described as Attribution 4.0 International